Nutritional rickets & osteomalacia: A practical approach to management
نویسندگان
چکیده
منابع مشابه
Hypophosphatemic rickets and osteomalacia.
The hypophosphatemic conditions that interfere in bone mineralization comprise many hereditary or acquired diseases, all of them sharing the same pathophysiologic mechanism: reduction in the phosphate reabsorption by the renal tubuli. This process leads to chronic hyperphosphaturia and hypophosphatemia, associated with inappropriately normal or low levels of calcitriol, causing osteomalacia or ...
متن کامل199 - Osteomalacia and rickets*
1997 Vitamin D is converted in the liver by a vitamin D-25-hydroxylase (25-OHase) to form the major circulating form of vitamin D, 25-hydroxyvitamin D [25(OH)D]. There have been at least four different 25-OHases identified both in mitochrondia and in microsomes. 25(OH)D is, however, biologically inert and requires hydroxylation in the kidneys on carbon 1 by the CYP27B mitrochondrial enzyme 25-h...
متن کاملRickets and osteomalacia
Although the relationship between rickets and vitamin D was recognized over 60 years ago it is only relatively recently that the metabolic pathway leading to the active form of vitamin D was recognized. We now understand that vitamin D in the form of one of its active metabolites is necessary for the maintenance of calcium homeostasis and we appreciate in part the mechanisms by which this is br...
متن کاملHypophosphataemic rickets/osteomalacia: a descriptive analysis.
BACKGROUND & OBJECTIVES Hypophosphataemic rickets/osteomalacia (HRO) is an uncommon metabolic bone disorder which affects all ages and either sex. It is characterized by low concentration of serum phosphate levels leading to impairment of mineralization of bone matrix with variable aetiology. We present clinical profile and treatment outcome of 17 patients of HRO. METHODS Seventeen consecutiv...
متن کاملRickets (Osteomalacia) — Symptoms and Treatment
Rickets, though not a common disease in the affiliated population, is one of the diseases which affect the growth of children in the developing countries (where the nutritional deficiency is common). Rickets can be characteristically identified using the clinical features and they can be confirmed using biochemical investigation. In this article, we will discuss the various features of rickets ...
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ژورنال
عنوان ژورنال: Indian Journal of Medical Research
سال: 2020
ISSN: 0971-5916
DOI: 10.4103/ijmr.ijmr_1961_19